I've started using Tweetdeck to keep track of multiple twitter accounts and Facebook, and it's pretty cool. One thing that seems to be odd though, is that if you add multiple accounts, the "Home" column will show the feed from the first twitter account added and the Facebook feed, but not a second twitter feed. It took me a while to figure this out. I decided the easiest thing to do then was to have three columns, a timeline for each twitter account, and the facebook news feed.
I didn't see anything about this in the help, and there don't appear to be any options to change what appears in the "Home" column.